Viagra associated with reduced risk of Alzheimer’s disease -NIH

According to NIH,  People who took the drug sildenafil were less likely to develop Alzheimer’s disease.

Also, in cultured human neurons, sildenafil enhanced growth and reduced Alzheimer’s biomarkers.

The findings support further investigation of sildenafil as a possible treatment for Alzheimer’s disease.

To understand how sildenafil might affect AD, the researchers grew neurons from stem cells derived from AD patients. Exposing the cells to sildenafil led to increased growth of neurites, which connect neurons to each other, and decreased tau phosphorylation, an early biomarker of AD.

Taken together, these results show an association between sildenafil use and reduced AD risk. But the researchers emphasize that they haven’t shown that sildenafil prevents or reverses AD. There may be other factors responsible for the association.

The institute further reports that this was discovered by a team of researchers led by Dr. Feixiong Cheng at the Cleveland Clinic.

"Because our findings only establish an association between sildenafil use and reduced incidence of Alzheimer’s disease, we are now planning a mechanistic trial and a phase II randomized clinical trial to test causality and confirm sildenafil’s clinical benefits for Alzheimer’s patients,” Cheng explains.

Alzheimer's disease is a progressively damages brain cells and leads to memory loss and is recorded as one of the leading courses of dementia. The changes in the brain usually begins years before the symptoms appear. 

The US Centre for Disease Control records that age is the best known risk factor for Alzheimer’s disease.

Image Credit: CDC.gov



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